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Archive for November 2nd, 2010

Nov 02 2010

Identification of 11 potential malaria vaccine candidates using bioinformatics

Posted by: Paul Chinnock - Editorial Team

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Dr Raul Isea has asked us to highlight his recently published research.

Identification of 11 potential malaria vaccine candidates using bioinformatics.

Abstract
In this paper, we suggested 11 protein targets to be used as possible vaccines against Plasmodium falciparum , the causative agent of almost two to three million deaths per year. A comprehensive analysis of protein targets have been selected from the small experimental fragment of antigen in the P. falciparum genome, all of them common to the four stages of the parasite life cycle (i.e., sporozoites, merozoites, trophozoites and gametocytes). The potential vaccine candidates should be analyzed in silico using various bioinformatics tools. The possible protein target according to PlasmoDB gene ID are PFC0975c, PFE0660c, PF08_0071, PF10_0084, PFI0180w, MAL13P1.56, PF14_0192, PF13_0141, PF14_0425, PF13_0322, y PF14_0598.

Isea R (2010). Identification of 11 potential malaria vaccine candidates using bioinformatics. VacciMonitor; 19(3)15-19. Full paper available online (Spanish only): http://sites.google.com/site/isearaul/home/vaccimonitor-isea.pdf

Dr Raul Isea works at the Instituto de Estudios Avanzados (IDEA) in Baruta, Venezuela.